PinnacleHealth participates in innovative clinical trial for heart failure patients
PinnacleHealth | 06.18.13
HARRISBURG, Pa. (June 18, 2013) -- On Monday, May 20, Brijeshwar Maini, MD, Cardiologist and Director of Cardiovascular Research and Education at PinnacleHealth, and Mubashir Mumtaz, MD, Chief of Cardiothoracic Surgery at PinnacleHealth, performed the first MitraClip procedure in the region as part of the COAPT research trial, (Clinical Outcomes Assessment of the MitraClip Percutaneous Therapy) for Extremely High Surgical Risk Patients. If the results of this clinical trial are positive, the MitraClip may offer patients with heart failure an improved quality of life and possibly less hospitalizations.
PinnacleHealth is one of 75 sites in the United States to participate in the randomized COAPT trial, a study of the use of the investigational MitraClip System, a less-invasive mitral valve repair therapy to treat mitral regurgitation (MR) in heart failure patients who are at too high risk for mitral valve surgery. Chronic, severe MR is often associated with heart failure and can result in death if left untreated. The MitraClip System may represent an important therapeutic option for patients with this debilitating disease, many of whom may have no other treatment options.
Dr. Maini explains:
“This new, cutting edge technique may offer high-risk heart failure patients, who previously didn’t have many options, the opportunity for an improved quality of life."
“It may help patients avoid hospitalizations. They want to breathe easier and live better, and we may be able to give them that if the COAPT trial yields positive results.”
Photo by Abbott Vascular
MitraClip device implanted.
Instead of open-heart surgery, the MitraClip System includes a catheter-based device that is delivered to the heart through the femoral vein, a blood vessel in the leg. This procedure is less invasive than traditional surgical options and also typically requires a shorter hospital stay. The MitraClip therapy is designed to reduce significant MR by clipping together the leaflets of the mitral valve, one of the four valves of the heart.
“This is a fairly simple procedure when compared to valve replacement, and PinnacleHealth is one of only two sites in Pennsylvania with access to this procedure through our participation in the COAPT trial,” explains Dr. Maini.
Significant MR is a debilitating condition in which the heart's ability to function continues to deteriorate over time, and may lead to irregular heartbeats, heart failure, stroke, heart attack or death. The condition traditionally has been managed with medications, which can relieve symptoms but do not address the underlying cause of the condition, or open-heart surgery. Many people who suffer from MR are not treated surgically because they are not referred to surgery, are not symptomatic enough, or are too frail for an invasive procedure.
Photo by Abbott Vascular
Mitral regurgitation shown with yellow arrows.
About Mitral Regurgitation (MR)
MR is the most common type of heart valve insufficiency, occurring when the leaflets of the mitral valve do not close completely, causing blood to flow backwards and leak into the left atrium of the heart during the cardiac cycle. To maintain an adequate forward flow of blood throughout the body, the heart compensates by increasing the size of the left ventricle (the main pumping chamber of the heart) to accommodate the increase in the volume of blood it is pumping. The chronic volume overload caused by MR requires the heart to work harder and may ultimately lead to heart failure and other complications. MR traditionally has been managed with drugs or open-heart surgery, depending on an individual patient's severity of MR and risk factors.
About PinnacleHealth System
PinnacleHealth is a pioneer not-for-profit healthcare system dedicated to providing and improving the health and quality of life for the people of Central Pennsylvania since 1873. A proven leader in medical innovation, PinnacleHealth offers a wide range of services from primary care to the most complex surgeries and Magnet recognition for nursing excellence. The healthcare network includes four campuses (Community, West Shore, Harrisburg and Polyclinic) and medical services, including family practice, imaging, outpatient surgery and oncology, at multiple locations throughout the region. For a complete list of services, visit our website at www.pinnaclehealth.org.
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